Watson-Crick Centre for Molecular Medicine
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    Dr. Muzafar Ahmad Macha

    Assistant Professor
    muzafar.aiiims@gmail.com
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Faculty Member
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1 Sinha P, Bahadur S, Thakar A, Matta A, Macha M and Ralhan R (2009). Significance of promoter hypermethylation of p16 gene for margin assessment in carcinoma tongue. Head and Neck. 31 (11):1423-30. PMID: 19431196. --Inter-National -- ( 06-12-2021 ) 
2 Sawhney M, Matta A, Macha MA, Gupta SD, Shukla NK and Ralhan R (2009). Cytoplasmic accumulation of Activated Leukocyte Cell Adhesion is a predictor of disease Progression and reduced survival in oral cancer patients. Int. J Cancer. 124(9):2098-105. PMID: 19142865. --Inter-National -- ( 06-12-2021 ) 
3 Kaur J, Demokan S, Tripathi SC, Macha MA, Begum S, Califano JA and Ralhan R (2010). Promoter hypermethylation in Indian primary oral squamous cell carcinoma. Int. J Cancer. 127(10):2367-73. PMID: 20473870. --Inter-National -- ( 06-12-2021 ) 
4 Macha MA, Matta A, Uma. S, Thakkar A, Shukla NK, Gupta SD and Ralhan R (2010). Clinical significance of TC21/R-Ras2 over expression in Oral Cancer. Journal of Oral Pathol and Med. 39(6):477-85. PMID: 20040018. --Inter-National -- ( 06-12-2021 ) 
5 Macha MA, Matta A, Kaur J, Thakkar JA, Chauhan SS, Shukla NK, Gupta SD and Ralhan R (2011). Prognostic significance of nuclear pSTAT3 in oral cancer. Head and neck. 33(4):482-89. PMID: 20652980.--Inter-National -- ( 06-12-2021 ) 
6 Macha MA, Matta A, Chauhan SS, Micheal KMS and Ralhan R (2010). 14-3-3 zeta is a Molecular Target in Guggulsterone Induced Apoptosis in Head and Neck Cancer Cells. BMC Cancer. 10(655): 1471-2407 PMID: 1118500.--Inter-National -- ( 06-12-2021 ) 
7 Ralhan R, Masui O, DeSouza LV, Matta A, Macha M and Michael KMS (2011). Identification of proteins secreted by head and neck cancer cell lines using LC-MS/MS: Strategy for discovery of candidate serological biomarkers. Proteomics. 11 (12):2363-76. PMID: 21598386.--Inter-National -- ( 06-12-2021 ) 
8 Macha MA, Matta A, Chauhan SS, Micheal KMS and Ralhan R (2011). Guggulsterone inhibits Smokeless Tobacco and Nicotine induced PI3K/Akt pathway in Head and Neck Cancer Cells. PLoS One. 24;6(2):e14728. PMID: 21383988. --Inter-National -- ( 06-12-2021 ) 
9 Macha MA, Matta A, Chauhan SS, Micheal KMS and Ralhan R (2011). Guggulsterone (GS) Inhibits Smokeless Tobacco and Nicotine Induced NF-kB and STAT3 pathways in Head and Neck Cancer cells. Carcinogenesis. 32(3):368-80. PMID: 21177768. --Inter-National -- ( 06-12-2021 ) 
10 Rachagani S, Macha MA, Ponnusamy PM, Haridas D, Kaur S, Jain M, and Batra SK (2012). MUC4 potentiates invasion and metastasis of pancreatic cancer cells through stabilization of fibroblast growth factor receptor 1. Carcinogenesis. 33(10):1953-64. PMID: 22791819.--Inter-National -- ( 06-12-2021 ) 
11 Rachagani S, Torres MP, Kumar S, Haridas D, Baine M, Macha MA, Jain M, Wagner K and Batra SK (2012). Expression of mucins in the progression of mouse pancreatic cancer in KrasG12D transgenic mouse model. J Hematol Oncol. 5(1):68. PMID: 23102107.--Inter-National -- ( 06-12-2021 ) 
12 Chakraborty S, Shimizu T, Gonzales TM, Souchek J, Kaur S, Macha MA, Rachagani S, Ganti AK, Hauke RJ, Moore ED and Batra SK (2013). Holy Basil leaf extract decreases tumorogenecity and metastasis of aggressive human pancreatic cancer cells in vitro and in vivo: potential role in therapy. Cancer Lett. 19(2):270-80. PMID: 23523869. --Inter-National -- ( 06-12-2021 ) 
13 Macha MA, Rachagani S, Suprit Gupta, Priya Pai, Ponusamy MP, Batra SK and Jain M (2013). Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling. Cancer Lett. 341(2):166-77. PMID: 23920124. --Inter-National -- ( 06-12-2021 ) 
14 Macha MA, Batra SK, and Ganti AK (2013). Profile of Vismodegib and its potential in the treatment of advanced basal cell carcinoma. Cancer Manag. Res. 31(5):197-203. PMID: 23940421.--Inter-National -- ( 06-12-2021 ) 
15 Macha MA, Seshacharyulu P, Krishn SR, Pai P, Rachagani S, Jain M and Batra SK (2014). MicroRNAs (miRNAs) as biomarker(s) for prognosis and diagnosis of gastrointestinal (GI) cancers. Curr Pharm Des. 20(33):5287-5297. PMID: 24479799. --Inter-National -- ( 06-12-2021 ) 
16 Macha MA, Rachagani S, Pai P, Gupta S, Lydiatt WM, Smith RB, Johansson S,. Lele SM, Kakar SS, Ibrahim FH, Lee JH, Jain M, and Batra SK (2014). MUC4 Regulates Cellular Senescence in Head and Neck Squamous Cell Carcinoma (HNSCC) through p16/Rb Pathway. Oncogene 34(13):1698-708. PMID: 24747969.--Inter-National -- ( 06-12-2021 ) 
17 Kamikawa Y, Kanmura Y, Hamada T, Yamada N, Macha MA, Batra SK, Higashi M, Yonezawa S, Sugihara K (2015). Combination of MUC1 and MUC4 expression predicts clinical outcome in patients with oral squamous cell carcinoma. Int. J of Clinical Oncol. 20(2):298-307. PMID: 24909613.--Inter-National -- ( 06-12-2021 ) 
18 Lakshmanan I, Ponnusamy MP, Macha MA, Haridas D, Majhi PD, Jain M, Batra SK, and Ganti AK (2015). Mucins in lung cancer: diagnostic, prognostic, and therapeutic implications. J Thorac Oncol. 10(1):19-27. PMID: 25319180.--Inter-National -- ( 06-12-2021 ) 
19 Rachagani S, Macha MA, Haridas D, Seshacharyulu P, Heimann N, Chugh S and Batra SK (2015). Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer. Advanced Drug Delivery Reviews. 81:16-33. PMID: 25453266. --Inter-National -- ( 06-12-2021 ) 
20 Macha MA§, Krishn SR, Jahan R, Banerjee K, Jain M* and Batra SK (2015). Emerging Potential of Natural Products for Targeting Mucins for Therapy against Inflammation and Cancer. Cancer Treatment Reviews 2015 41(3):277-288. (§Corresponding author) PMID: 25624117. --Inter-National -- ( 06-12-2021 ) 
21 Rachagani S, Macha MA, Menning M, Haridas D, Dey P, Johansson SL, Smith LM, Kumar S and Batra SK (2015). Micro RNA (miRNA) changes during the initiation and progression of pancreatic cancer in the genetically engineered mice. Oncotarget 24;6(37):40295-309 PMID: 26516699. --Inter-National -- ( 06-12-2021 ) 
22 Pai P, Rachagani S, Lakshmanan I, Macha MA, Sheinin Y, Smith LM, Ponnusamy PM and Batra SK (2016). The Canonical Wnt Pathway Regulates the Metastasis-Promoting Mucin MUC4 in Pancreatic Ductal Adenocarcinoma. Molecular Oncology 10(2):224-39. PMID: 26526617.--Inter-National -- ( 06-12-2021 ) 
23 Pai P, Rachagani S, Dhawan P, Sheinin YM, Macha MA, Qazi AK, Chugh S, Ponnusamy MP, Mallya K, Pothuraju R and Batra SK (2016). MUC4 is negatively regulated through the Wnt/β-catenin pathway via the Notch effector Hath1 in colorectal cancer. Genes Cancer 7(5-6):154-168. PMID: 27551331. --Inter-National -- ( 06-12-2021 ) 
24 Macha MA§, Rachagani S, Qazi AK, Jahan R, Gupta S, Patel A, Seshacharyulu P, Lin C, Li S, Wang S, Verma V, Kishida S, Kishida M, Nakamura N, Kibe T, Lydiatt WM. Ganti AK, Jones DT, Batra SK and Jain M (2017). Afatinib radiosensitizes Head and Neck Squamous Cell Carcinoma by targeting cancer stem cells. Oncotarget 8(13):20961-20973 (§Corresponding author). PMID: 28423495.--Inter-National -- ( 06-12-2021 ) 
25 Jahan R, Macha MA, Rachagani S, Smith L, Kaur S and Batra SK (2018). Axed MUC4 (MUC4/X) aggravates pancreatic malignant phenotype by activating Integrin-β1FAK/ERK pathway (BBA-Molecular Basis of Disease. 1864(8):2538-2549. PMID: 29777904. --Inter-National -- ( 06-12-2021 ) 
26 Qazi AK *, Siddiqui J *, Jahan R *, Chaudhary S, Walker LA, Syed Z, Jones DT, Batra SK and Macha MA§ (2018). Emerging Therapeutic Potential of Graviola and its Constituents in Cancers. Carcinogenesis, 39(4):522-533. §Corresponding author). PMID: 29462271. --Inter-National -- ( 06-12-2021 ) 
27 Vengoji R, Rachagani S, Mahapatra S, Batra SK, Shonka NA and Macha MA § (2019)..Novel Therapies Hijack the Blood Brain Barrier to Eradicate Glioblastoma Cancer Stem Cells. Carcinogenesis, 40(1):2-14. PMID: 30475990.--Inter-National -- ( 06-12-2021 ) 
28 Chaudhary S*, Ganguly K*, Muniyan S, Pothuraju R, Sayed Z, Jones DT, Batra SK and Macha MA§ (2019). Immunometabolic Alterations by HPV Infection: New Dimensions to Head and Neck Cancer Disparity. Journal of National Cancer Institute, 111(3):233-244. §Corresponding author) PMID: 30615137. --Inter-National -- ( 06-12-2021 ) 
29 Jahan R, Ganguly K, Smith L, Sheinin Y, Atri P, Carmicheal J, Rachagani S, Natarajan G, Brand RE, Macha MA, Grandgenett PM, Kaur S and Batra SK (2019). Trefoil factor(s) and CA19.9: A promising panel for early detection of pancreatic cancer. EBioMedicine, 42:375-385. PMID: 30956167. --Inter-National -- ( 06-12-2021 ) 
30 Vengoji R, Macha MA, Nimmakayala RK, Rachagani S, Siddiqui JA, Gupta S, Mallaya K, Koranta S, Jain M, Batra SK and Shonka NA (2019). Combination of afatinib and temozolomide prevents tumor recurrence by targeting EGFRVIII-cMet signaling in glioblastoma stem cells. J Exp Clin Cancer Res 38(1):266. PMID: 31215502--Inter-National -- ( 06-12-2021 ) 
31 Bhat AA, Syed N, Therachiyil L, Nisar S, Hashem S, Krishnankuty R, Macha MA, Yadav SK, Bagga P, Reddy R, Shanmagaonkar M, Al-Naemi H, Dhawan P, Uddin S, El-Rifai W and Haris M (2020). Claudin-1, A Double-Edged Sword in Cancer. Int J Mol Sci. 21 (2):569 PMID: 31952355. --Inter-National -- ( 06-12-2021 ) 
32 Nisar S, Hashem S, Macha MA, Yadav SK, Muralitharan S, L Azeez, Sageena G, Al-Naem H, Haris M, Bhat AA (2020). Exploring Dysregulated Signaling Pathways in Cancer. Curr Pharm Des. 26(4):429-445 PMID: 31939726.--Inter-National -- ( 06-12-2021 ) 
33 Hashem S, Nisar S, Sageena G, Macha MA, Yadav SK, Krishnankutty R, Haris M, Uddin S, Haris M and Bhat AA (2020). Therapeutic effects of Curcumol in several diseases; An overview. Nutrition Cancer, 14;1-15. PMID: 32285707.--Inter-National -- ( 06-12-2021 ) 
34 Jahan R, Shah A, Kisling MS, Macha MA, Thayer S, Kaur S and Batra SK (2020). Odyssey of Trefoil factors in Cancers: Diagnostic and Therapeutic Implications. BBA-Reviews Cancer. 13:188362. PMID: 32298747. --Inter-National -- ( 06-12-2021 ) 
35 Chaudhary S, Dam V#, Ganguly K#, Sharma S#, Atri P#, Chirravuri R#, Jesse L. Cox, Sayed Z, Jones DT, Ghersi D§, Macha MA§ and Batra SK§ (2020). Differential mutation spectrum and immune landscape in African Americans versus whites: A possible determinant to health disparity in head and neck cancer. Cancer Letters, 29: S0304-3835(20)30386-4. §Corresponding author. PMID: 32738272. --Inter-National -- ( 06-12-2021 ) 
36 Nisar S, Bhat AA, Hashe S, Yadav SK, Bagga P, Macha MA, Frenneaux MP, Reddy R, Haris M (2020). Non-invasive biomarkers for monitoring the immunotherapeutic response to cancer. Journal of Translational Medicine, 9;18(1):471. PMID: 33298096.--Inter-National -- ( 06-12-2021 ) 
37 Bhat AA, Yousuf P, Wani NA, Nisar S, Chauhan SS, Siddiqui MA, Bedognetti D, El-Rifai W, Frenneaux MP, Batra SK, Harris M§, Macha MA§ (2021). Tumor Microenvironment Mediated Aggressive Head and Neck Squamous Cell Carcinoma: Novel Avenue for Therapeutic Targeting. Signal Transduction and Therapeutic Targeting, 12;6(1):12. §Corresponding author. PMID: 33436555. --Inter-National -- ( 06-12-2021 ) 
38 Bhat AA§, Nisar S, Macha S, Carneiro-Lobo TC, Akhter S, Siveen KS, Hashem S, Wani NA, Uddin S, Siddiqui MA, Frenneaux MP, Bedognetti D, El-Rifai W, Macha MA§ and Haris M§ (2021). Chemokine-Cytokine Network Drives Esophageal Cancer Metastasis; Promising Avenue for Targeted Therapy. Molecular Cancer, 4;20(1):2. §Corresponding authors. PMID: 33390169. --Inter-National -- ( 06-12-2021 ) 
39 Nisar S, Bhat AA, Singh M, Karedath T, Rizwan A, Yadav SK, Hashem S, Bagga P, Reddy R, Jamal F, Uddin S, Chand G, El-Rifai W, Frenneaux MP, Macha MA, Ahmed I, Haris M (2021). Insights into the role of circRNAs: biogenesis, characterization, functional and clinical impact in human malignancies. Front Cell Dev Biol. 5; 9:617281. PMID: 33614648.--Inter-National -- ( 06-12-2021 ) 
40 Nisar S, Yousuf P, Wani NA, Hashem S, Singh M, Sageena G, Mishra D, Harris M, Bhat AA§ and Macha MA§ (2021). Chemokine Cytokine Networks in the Head and Neck Tumor Microenvironment. Int J Mol Sci. 22(9)4584:1-23 §Corresponding author. PMID: 33925575. --Inter-National -- ( 06-12-2021 ) 
41 Chaudhary S, Pothuraju R, Rachagani S, Siddiqui JA, Atri P, Mallya K, Nasser MW, Sayed Z, Lyden ER, Smith L, Gupta SD, Ralhan R, Lakshmanan I, Jones DT, Ganti AK§, Macha MA§, Batra SK§ (2021). Dual targeting EGFR and CDK4/6 Delays Head and Neck Squamous Cell Carcinoma Progression in Genetically Engineered Mouse Model by Inducing Metabolic Rewiring Cancer Letters 10(510):79-92 §Corresponding author. PMID: 33878394. --Inter-National -- ( 06-12-2021 ) 
42 Lone NS, Bhat AA, Wani NA, Karedath T, Hashem S, Nisar S, Singh M, Bagga P, Das BC, Bedognetti D, Reddy R, Frenneaux MP, El-Rifai W, Siddiqi MA, Haris M§ and Macha MA§, (2021). miRNAs as Novel Immune System Regulators in Cancer. Semin Cell Dev. Biol. 26:S1084-9521(21)00086-0 §Corresponding author. PMID: 33926791.--Inter-National -- ( 06-12-2021 ) 
43 Meraj U, Ganai RA, Macha MA, Hamid A, Zargar MA, Bhat AA, Nasser WM, Haris M, Batra SK, Alshehri B, Al-Baradie RS, Mir MA and Wani NA (2021). Tumor Microenvironment as Driver of Stemness and Therapeutic Resistance in Breast Cancers: New Challenges and Therapeutic Opportunities. Cellular Oncology (Dordr). PMID: 34528143--Inter-National -- ( 06-12-2021 ) 
44 Vengoji R, Atri P, Macha MA, Seshacharyulu P, Perumal K, Liu Y, Smith LM, Rachagani S, Mahapatra S, Ponnusamy MP, Jain M, Batra SK and Shonka NA (2021). Differential gene expression-based connectivity mapping identified novel drug candidate and improved Temozolomide efficacy for Glioblastoma. Journal of Experimental & Clinical Cancer Research. 25;40(1):335. PMID: 34696786--Inter-National -- ( 06-12-2021 ) 
45 Chauhan R, Bhat AA, Masoodi T, Sheikh ZA, Macha MA, Haris M, and Singh M (2021). Ubiquitin specific peptidase 37 (USP37), An important cog in oncogenic machinery of a cancerous cell. Journal of Hematology and Oncology, 10;40(1):356. PMID: 34758854--Inter-National -- ( 06-12-2021 ) 
S.No.Project TitleProject StatusFunding AgencyPI COPI InvestgatorAmount of GrantDuration
1 Development and characterization of in vitro models to identify novel therapeutic targets for Indian Esophageal Cancer patients.OngoingDBTPrincipal Investigator113.605 years
2 Systems biology-based identification and validation of potential novel therapeutic agents for Head and Neck Squamous Cell CarcinomaOngoingSERB-DSTPrincipal Investigator51.10 3 years
3 Artificial intelligence Based Deep Learning Model to Predict Gastric Cancer Tumor Heterogeneity and Therapeutic Response Using Histopathology ImagesOngoingICMRPrincipal Investigator21.70 2 Year
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